基于磷酸化蛋白质组学结果，图7A列出了可成药的主导靶点。免疫组化染色显示BCL2在三种蛋白质组学分型中表达具有异质性：在Pro-I亚型中高表达，而在Pro-III亚型中表达水平较低。Pro-II亚型患者中PD-L2上调和DNA修复信号增强。Pro-III亚型侵袭性最强，以高频BRAFV600E突变及CD274、C5AR1高表达为特征。在免疫健全小鼠模型中，单用阿伐可泮或抗PD-1抗体仅显示中等抗肿 ...

Ed Bolen believes that total control of the ATC system is the force majeure behind the airlines’ long-held wish to create and dominate an air traffic control corporation supported by user fees. “For ...