Bringing medical advances from the lab to the clinic.关键词：#征战CA #Healsan临床科研小细胞肺癌（SCLC）是神经内分泌（NE）肿瘤中最具侵袭性的类型，5年生存率仅约5%。临床与细胞系数据均显示，80%以上SCLC缺失caspase 8蛋白表达，传统观点将其功能局限于“逃避外源性凋亡”。然而，正常神经干/祖细胞亦缺乏caspase .

The parasite that may already live in your brain can infect the very immune cells trying to destroy it, but new UVA Health ...

Researchers have identified a previously unknown inflammatory mechanism that may drive the aggressiveness and relapse of small cell lung cancer. Small cell lung cancer (SCLC) is among the most ...

Caspase-8 is frequently deficient in several kinds of human tumors, suggesting that certain effects of this enzyme restrict tumor development. To examine the nature of the cellular function whose ...

这篇综述系统阐述了半胱氨酸蛋白酶（caspases）在程序性细胞死亡（PCD）中的核心作用，涵盖细胞凋亡（apoptosis）、焦亡（pyroptosis）、坏死性凋亡（necroptosis）和铁死亡（ferroptosis）等通路。文章详细解析了caspases通过表观遗传调控、分子互作和翻译后修饰（PTMs ...

Figure 1: CYLD is essential for necrosis. Figure 2: CYLD is a substrate for proteolysis by caspase 8. Figure 4: CYLD D215A triggers programmed necrosis in the absence of caspase inhibitors. Figure 5: ...

Researchers at the University of Cologne discovered a new mechanism used by one of the most aggressive forms of lung cancer to escape treatment, paving the way for more efficient future therapies / pu ...