The centrosome, consisting of a pair of centrioles and pericentriolar material (PCM), is the major microtubule-organizing centre (MTOC) of many eukaryotic cells. Centrosome duplication and MTOC ...

Centrosome amplification is frequent in cancer, but the underlying mechanisms remain unclear. Here we report that disruption of the Kruppel-like factor 14 (KLF14) gene in mice causes centrosome ...

The cover for issue 26 of Oncotarget features Figure 6, "Mislocalization of IQGAP1-BRCA1 in human TNBC tumors phenocopies the dominant mutants and the TNBC cells," by Osman, et al. and reported that ...

This is a preview. Log in through your library . Abstract The centrosome functions as the major microtubule-organizing center and plays a vital role in guiding chromosome segregation during mitosis.

Centrosomes are small structures in cells with many essential functions, including roles in cell signaling and in organizing a cell’s cytoskeleton. Centrosome dysfunction contributes to diseases like ...

A recent Cell Reports paper by the Oxenius group (IMB) demonstrates a function of targeted centrosome inheritance during CD8+ T cell division for the generation of memory precursor cells.

Stem cell self-renewal can be specified by local signals from the surrounding microenvironment, or niche. However, the relation between the niche and the mechanisms that ensure the correct balance ...

Non Adherence to Post Surgery Annual Surveilance Mammogram and Follow Up Among Breast Cancer Survivors in a Tertiary Care Hospital in Malaysia Modern chemotherapeutics frequently suffer from selective ...

MBL, WOODS HOLE, MA--Despite more than a century of study, scientists know relatively little about the inner workings of centrosomes--organelles essential to cell division in humans and animals. Now ...

A basic requirement for growth and life of a multicellular organism is the ability of its cells to divide. Chromosomes in the cells duplicate and are then distributed among the daughter cells. This ...

New research by scientists studying surf clams at the MBL (Marine Biological Laboratory) shows that centrosomes may contain ribonucleic acid (RNA), the molecule that translates genes into proteins.