Eicosanoid pathways have a major role in the pathogenesis of rheumatic diseases, including rheumatoid arthritis, osteoarthritis, idiopathic inflammatory myositis, systemic lupus erythematosus and ...

In this study, using both in vitro and in vivo models, we demonstrate the signaling mechanism by which OPN regulates macrophage activation that further controls melanoma growth and angiogenesis. Our ...

Arachidonic acid (ARA) is metabolized by cyclooxygenase (COX) and cytochrome P450 to produce proangiogenic metabolites. Specifically, epoxyeicosatrienoic acids (EETs) produced from the P450 pathway ...

August 30, 2007 (Farmingham, CT) – A new mouse study published this week provides some insight into understanding why rofecoxib (Vioxx, Merck) and the other cyclooxygenase (COX)-2 inhibitors increase ...

COX-2 plays a pivotal role in ferroptosis during the progression of chronic liver disease, as it downregulates the Nrf2 signaling pathway, exacerbating ferroptosis, which is characterized by ferrous ...