Cytochrome P450 (P450) and chloroperoxidase (CPO) are thiolate-ligated haem proteins that catalyse the activation of carbon hydrogen bonds. The principal intermediate in these reactions is a ferryl ...

来自中国浙江大学等机构的科学家们通过对HCC的性别异质性背后的机制进行了深入分析，或有望帮助识别出女性群体中存在的关键HCC抑制机制，相关研究结果或有望帮助开发治疗肝细胞癌患者的新型疗法。 2022年1月20日 讯 /生物谷BIOON/ --肝细胞癌（HCC ...

Cytochrome P450 mono-oxygenases (P450s) are the principal enzymes involved in the oxidative metabolism of drugs and other xenobiotics. In this protocol, we describe a fluorescence-based, ...

Neurodegenerative disorders are pressing global health challenges that stem from progressive neuronal dysfunction and loss. While the central roles of ...

本研究通过系统整合细胞色素P450-CPR（Cytochrome P450 reductase）工程与辅因子代谢网络重构，在酿酒酵母（Saccharomyces cerevisiae）中 ...

Cytochrome P450 (CYP450), is a family of hemoglobin-coupled monooxygenases. In mammals, CYP450 oxidizes steroids, fatty acids, and xenobiotics, playing an important role in the metabolism of various ...

Clopidogrel requires transformation into an active metabolite by cytochrome P-450 (CYP) enzymes for its antiplatelet effect. The genes encoding CYP enzymes are polymorphic, with common alleles ...

Effect of IL-6 and related mediators on resistance to abiraterone acetate (abi) and enzalutamide (enza) in patients with metastatic castration-resistant prostate cancer (mCRPC). This is an ASCO ...

Outcome After Pathologic Complete Eradication of Cytologically Proven Breast Cancer Axillary Node Metastases Following Primary Chemotherapy We determined cytochrome P450 (CYP)2D6 (*4 and *6) and ...