撰文丨王聪编辑丨王多鱼排版丨水成文疱疹病毒是广泛存在的双链 DNA 病毒，可终身潜伏并引发多种疾病。尽管靶向 DNA 聚合酶的抗病毒药物有效，但日益增强的耐药性凸显了寻找替代药物的必要性。解旋酶-引物酶抑制剂（Helicase-primase ...

Saccharomyces cerevisiae telomeres consist of ∼350 base pairs of the sequence C 1–3 A/TG 1–3. As in most eukaryotes, yeast telomeric DNA is elongated by telomerase, a specialized reverse transcriptase ...

本研究针对解旋酶(Helicase)靶点开发滞后的问题，通过整合ChEMBL数据库的化学基因组学数据，构建了首个全面注释的解旋酶抑制剂数据库Heli-SMACC，包含13,597个分子和20,431条生物活性数据。团队筛选出12个可抑制SARS-CoV-2 NSP13 ATPase活性的先导化合物，为抗病毒药物 ...

近日，大连理工大学、中科院天津工业生物技术研究所研究团队在《Metabolic Engineering》上发表题为“Helicase-AID: A novel molecular device for base editing at randomgenomic loci”的研究论文，将DNA解旋酶与脱氨酶结合形成“Helicase -AID”复合物，分别在大肠杆菌和酿酒酵母中应用 ...

Harvard Medical School researchers have uncovered crucial insights into how an emerging class of antiviral drugs works.

SOUTH SAN FRANCISCO, Calif., Oct. 10, 2025 (GLOBE NEWSWIRE) -- Assembly Biosciences, Inc. (Nasdaq: ASMB), a biotechnology company developing innovative therapeutics targeting serious viral diseases, ...

FOSTER CITY, Calif. & SOUTH SAN FRANCISCO, Calif., December 22, 2025--Gilead Sciences, Inc. (Nasdaq: GILD) and Assembly ...

The RNA helicase DDX3X spends its days unwinding RNA:RNA duplexes and binding key mediators of RNA metabolism. A regulator of RNA transcription, splicing, nuclear export, and translation, DDX3X plays ...

Researchers have identified the mechanism used by the helicase ring to thread around and separate entwined DNA strands in the replication process. DNA replication is a complex process in which a ...