The central dogma processes of DNA replication, transcription, and translation are responsible for the maintenance and expression of every gene in an organism. An orthogonal central dogma may insulate ...

Our ability to routinely engineer genetic networks for applications is limited by the scarcity of highly specific and non–cross-reacting (orthogonal) gene regulators with predictable behavior. Though ...

Discordance between plasma and tumor variant calling has been attributed primarily to tumor heterogeneity, whereas technical variables remain largely unexplored. Our orthogonal approach identified ...

From RNA interference (RNAi) to CRISPR, there are several methods that researchers can use to manipulate gene function, each with its own strengths and weaknesses. Orthogonal validation – the ...

One of the fundamental purposes of biotherapeutic research, development, and production is to assure the safety and efficacy of medicinal products in clinical settings. Analytical tools are critical ...

Simply put, orthogonal validation uses additional methods that provide very different selectivity to the primary method to confirm or refute a finding. All methods are independent approaches that can ...

Orthogonal Thinker, Inc. (“Orthogonal” or the “Company”) today announced Vision 2030, a long-term strategic framework positioning the Company ...

Orthogonal frequency-division multiple-access provides Wi-Fi 6 with high throughput and more network efficiency by letting multiple clients connect to a single access point simultaneously. Wi-Fi 6, ...