Figure 3: Various scaffolds utilized to engineer binders to Ras and their binding epitopes. Ras proteins are small GTPases that regulate cell growth and division. Mutations in Ras genes are associated ...

How does a proto-oncogene cause cancer? In the early twentieth century, a tumor-causing virus called the Rous sarcoma virus (retrovirus) was discovered. 3 Host cell proto-oncogene (c-src) and Rous ...

Two original papers in Nature highlight the discovery and translational implications of RMC-7977, a RAS(ON) multi-selective tri-complex inhibitor that exhibits unprecedented anti-tumor activity in ...

Revolution Medicines is a clinical-stage pharma company with a market cap of ~6 billion. It has ample liquidity to support its current business plan into 2027. Its pipeline directed entirely towards ...

Peking University, June 1, 2025: To address the challenge of controlling protein activation in living animals for gain-of-function studies, researchers from Peking University led by Professors Chen ...