Mdm2 overexpression confers a growth promoting activity upon cells primarily by downregulating the p53 tumor suppressor protein. Nevertheless, Mdm2 deregulation has also been implicated in inhibiting ...

Transforming growth fazctor-β (TGFβ) family members regulate many developmental and pathological events through Smad transcriptional modulators. How nuclear accumulation of Smad is coupled to the ...

在细胞信号传导研究中，为探究 R-SMADs 在细胞核内的失活机制，研究人员开展了关于 TGF-β/SMAD 信号通路的研究。结果发现 CTDNEP1-NEP1R1 磷酸酶复合物可使 R-SMADs 去磷酸化，该发现揭示了 TGF-β 信号失活机制，对理解相关疾病意义重大。 在生命科学的微观世界里 ...

本综述系统阐述了双重SMAD抑制技术（通过同时抑制TGF-β和BMP信号通路）在高效诱导人多能干细胞（hPSCs）向神经谱系分化中的 ...

David C. Clarke, Meredith D. Betterton, and Xuedong Liu (2006). IEE Proceedings Systems Biology 153 (6). Download. Transforming growth factor-beta (TGFbeta) signalling is an important regulator of ...