Different chronic pain states generate different neurochemical changes in sensory fibres and the spinal cord. Understanding these distinct molecular signatures might be the key to effective pain ...

Salk scientists uncover a key neural circuit in mice that gives pain its emotional punch, opening new doors for treating fibromyalgia, migraine, and PTSD LA JOLLA (July 9, 2025)—Pain isn’t just a ...

Pinprick response is a longstanding feature of the clinical examination for spinal cord damage, but this test cannot target every afferent pathway in the spinothalamic tract. Haefeli et al. applied ...

Stanford Medicine investigators have replicated, in a lab dish, one of the most prominent human nervous pathways for sensing pain. This nerve circuit transmits sensations from the body’s skin to the ...

Pain isn’t just a physical sensation—it also carries emotional weight. That distress, anguish, and anxiety can turn a fleeting injury into long-term suffering. Researchers at the Salk Institute have ...