Drug dependence is a major worldwide public health problem. In drug addicts, one of the main unsolved challenges is eradicating the pathological motivation for the drug without impairing the general ...

Study shows that activity in the subthalamic nucleus reflects action outcomes and consequent adaptation in humans; this can be modified through bursts of electrical stimulation, with potential to ...

Researchers have identified a new neural circuit in the brain which produces a strong sense of discomfort when activated. The discovery also allows them to show for the first time that the subthalamic ...

Researchers have applied a chemogenetic tool in macaque monkeys and suppressed the subthalamic nucleus, a part of the basal ganglia circuitry. The chemogenetic suppression induced unstable movements.

(A) Experimental design. (B) Behavior assessments using open field tests. Heatmaps illustrate time spent (red) and movement trajectories (green). The PD group exhibited decreased movement speed ...