An important goal in drug development is to engineer inhibitors and ligands that have high binding affinities for their target molecules. In optimizing these interactions, the precise determination of ...

Isothermal titration calorimetry (ITC) is an analytical technique, which is often thought of as the gold standard for analyzing intermolecular interactions. It is a titrimetric method, which is a ...

Complexes, such as protein/protein, nucleic acids/nucleic acid, protein/nucleic acid, protein/ligand, nucleic acid/ligand, are often difficult to crystallize even on well-defined biological systems, ...

Karl Fischer discovered that if sulfur dioxide is added in the excess the same reaction can be used for water determination by titration of the produced acids. His base of choice was pyridine which ...