Individuals with β-thalassemia develop progressive systemic iron overload, resulting in high morbidity and mortality. These complications are caused by labile plasma iron, which is taken up by ...

The potential of targeting nanomedicines has already been illustrated in practice 5,6,7. Among the known approaches, nanomedicines that exploit active targeting via specific ligands are becoming ...

The blood brain barrier (BBB) exists to protect the brain from pathogens and other toxins but makes central nervous system (CNS) diseases hard to treat with conventional drugs. For example, many ...

A new study led by researchers at the Graduate Entry Medical School (GEMS), University of Limerick (UL) has found that people with low levels and very high levels of a commonly measured laboratory ...

Incorporating structural constraints into pharmacokinetic studies of iron sucrose formulations. Results from assays conducted independently of one another can produce findings that are incompatible ...

NEW YORK--(BUSINESS WIRE)--Apertura Gene Therapy, a biotechnology company opening opportunities in genetic medicine for treating debilitating diseases with limited options, today unveiled its ...

The dynamic balance of iron and lipid metabolism is essential for maintaining cellular energy supply. Not only does iron play a key role in cellular respiration, DNA synthesis, and antioxidant ...

Over the last three decades, scientists have devised molecular shuttles that slip enzymes, antibodies, and other molecules into the central nervous system (CNS) by attaching them to the transferrin ...

For decades scientists have sought a way to sneak large drugs across the blood-brain barrier. These efforts received a boost in 2011, when researchers led by Ryan Watts at Genentech, South San ...

Researchers have identified that a glycoprotein known as transferrin may critically contribute to severe forms of COVID-19. The University of Kent's School of Biosciences and the Institute of Medical ...