Nature

PINning down the c-Myc oncoprotein

The proto-oncogenic transcription factor c-Myc is a central regulator of the cell cycle and cell growth. Amino-terminal phosphorylation of c-Myc results in its proteasomal degradation. A new study ...
生物通

Cell综述：通往癌症道路上的MYC

在最新一期（3月30日）的《细胞》（Cell）杂志上，来自美国宾夕法尼亚大学佩雷尔曼医学院的Chi V. Dang发表了一篇题为“MYC on the Path to Cancer”的综述文章，为我们深入了解MYC的分子功能、相关信号通路及在癌症发生发展中的角色提供了重要的资料。 生物通报道 ...
Nature

Defining the specific physiological requirements for c-Myc in T cell development

Figure 1: Development of c-Myc −/− and c-Myc +/− ES cells. Figure 3: c-Myc −/− cells do not efficiently complete thymocyte differentiation in adult RAG-1 −/− chimeras. Figure 4: c-Myc −/− cells do not ...

Nature子刊：香港理工大学团队揭示肝癌免疫治疗耐药新机制：野生型 ...

肝细胞癌是世界上第三大致命性癌症和第六大常见癌症。近年来，免疫检查点抑制剂（ICIs）在晚期HCC治疗中展现出潜力，提高了存活率，但仅部分患者受益。越来越多的证据表明，致癌通路的激活会导致肿瘤免疫微环境（TIME）恶化，最终引发免疫治疗抵抗。2025年11月11日，香港理工大学Terence Kin Wah Lee团队在Nature Communications（IF 15.7）上发表了题为“Wi ...
生物通

两篇Nature文章： 深入探究Myc的功能机制

发表在7月9日《自然》（Nature）杂志上的两篇新文章，提供了有关Myc在正常和癌细胞中发挥不同作用的一些新见解，并证实了Myc可选择性地调控基因表达。 生物通报道 在正常细胞增殖过程中Myc基因表达受到严格调控，而在人类癌症中往往出现调控异常，此外 ...
EurekAlert!

A novel mechanism for overexpression of c-Myc, a proto-oncogene in cancer cells

The c-Myc oncoprotein is frequently overexpressed in human cancers and is essential for cancer cell proliferation. The dysregulation of ubiquitin-proteasome-mediated degradation is one of the ...
ascopubs.org

c-Myc expression as a key-marker in the colorectal cancer resistance to EGFR inhibitors.

Preliminary safety and activity of perioperative triplet chemotherapy plus bevacizumab (bev) in patients with borderline resectable colorectal cancer liver metastases (CLM). Final phase II trial ...
JSTOR Daily

Global Mapping of c-Myc Binding Sites and Target Gene Networks in Human B Cells

Karen I. Zeller, XiaoDong Zhao, Charlie W. H. Lee, Kuo Ping Chiu, Fei Yao, Jason T. Yustein, Hong Sain Ooi, Yuriy L. Orlov, Atif Shahab, How Choong Yong, YuTao Fu ...
Fred Hutch

When it comes to MYC, it doesn’t take much

So, what insight are we left with? “On the highest level,” notes Dr. Eisenman, “this study really demonstrates that a single amino acid substitution in a single protein is enough to predispose the ...
ascopubs.org

Taking on Challenging Targets: Making MYC Druggable

Novel Treatment Targets in Sarcoma: More Than Just the GIST MYC has proven to be a highly potent oncoprotein when it is overexpressed, but is also a pleiotropic transcription factor essential for ...
Science Daily

New roles for common oncogene MYC

Cancer researchers have discovered surprising new functions for a protein called MYC, a powerful oncogene that is estimated to drive the development of almost half a million new cancer cases in the US ...