人类人工染色体HAC从头合成一直受限于着丝粒复杂结构的构建难题，新一期Science报告了人类人工染色体工程新突破：一种有效地生成单拷贝HACs的方法，约750kb的构建体足够容纳着丝粒上的多域染色质，避免了多聚化问题。新方法将为哺乳动物细胞背景下进行忠实 ...

近期，海南橡胶（601118.SH）发布了《重大资产购买报告书（草案）》（以下简称“草案”），拟通过境外SPV收购中化新所持有 ...

Kinetochores are essential for proper chromosome segregation. The site of kinetochore assembly has been proposed to be controlled by epigenetic mechanisms; however, the chromatin 'signature' of human ...

Every vector system currently available for gene therapy has some drawbacks and advantages. 1 The use of viral vectors such as retroviral and lentiviral vectors allow for the improved duration of ...