Afadin-deficient mice, whose outer-retinal lamination and photoreceptor synapses are severely disrupted, nonetheless partially retain retinal neural circuits and visual function.

Organoid Intelligence (OI) represents a groundbreaking convergence of biology and technology, aiming to redefine biocomputing using brain organoids—three-dimensional neural structures derived from ...

In this article, we examine ongoing challenges shaping target-based drug discovery and highlight how new technologies and interdisciplinary approaches are helping to address them.