What are the differences between internal receptors and cell-surface receptors? a. Internal receptors bind to ligands that are hydrophobic and the ligand-receptor complex directly enters the nucleus, initiating transcription and translation. Cell surface receptors bind to hydrophilic ligands and initiate a signaling cascade that indirectly influences the making of a functional protein. b. Internal receptors bind to ligands that are hydrophilic and ligand-receptor complex directly enters the nucl

Ligand | Definition, Examples & Properties