Liquid chromatography column technology has come a long way over the years. Traditional 4.6-mm internal diameter (i.d.) columns packed with 5-µm particles are being replaced with smaller i.d. columns (2.1 mm) packed with smaller, sub-2-µm particles to increase column efficiency. Claims have been made that you can get improvements simply by utilizing a high-efficiency column on your existing HPLC system. In this episode of #TrustYourScience, Kim and Jon take a look at using narrow bore, high-effi